| 초록 |
Amphiphilic block copolymers assemble into nanoscopic core-shell structures, self-aggregates, which are of considerable interest for the delivery of hydrophobic anticancer drug. In this study focused on achieving prolonged circulation times for passive targeting of chemotherapeutic agents and environment sensitivity of the self-aggregates. We designed polymeric aggregates with Poly(ethylene glycol) and Poly(ε-caprolactone) based copolymer containing functional groups between two block segments for drug delivery. Poly(ethylene glycol) are sterically stabilized and undergo less opsonization and uptake by the macrophages of the reticuloendothelial system (RES), allowing the aggregate to circulate longer in blood. Semi-crystalline part of Poly(ε-caprolactone) block is biodegradable and resorbable in a suitable period of time. Functional groups are thiol residues which form disulfide bond that lead to reduction-sensitive release of anticancer drug. |
