| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Dual responsive polymeric micelle for cell Imaging and drug delivery |
| 초록 |
This paper reports the development of dual responsive polymeric micelles having pH responsive boronate ester and DTT responsive disulfide bonds to deliver anticancer drug Taxol. The facile conjugation between Pluronic and Chitlac with Poly (DMA-MAA-SP-BA) (Plu-Chit/PDMSB) was confirmed by 1H NMR, UV-Vis and Fluorescence spectroscopy and DLS before and after loading the drug. The prepared micelles show strong fluorescence due to conversion from SP to merocyanine (MC) form. Taxol loading content was 7.66 % with 83.62% loading efficiency. Cellular uptake of the Taxol loaded micelles was confirmed via CLSM. These polymeric micelles can be used as a carrier of hydrophobic anticancer drug delivery system. This facile strategy can be a useful platform to deliver anticancer drug and detect cancer cells. |
| 저자 |
Fatema Khatun, 박성영
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| 소속 |
한국교통대 |
| 키워드 |
pH responsive; redox responsive; spiropyran; cell imaging; micelle; drug delivery
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| E-Mail |
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