| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Losartan Potassium-Hydrochlorothiazide Bilayer Formulation for Controlled Release |
| 초록 |
Bilayer formulation is a convenient method for simple treatment with oral administration. This formulation was formed with the objective to control dissolution kinetics by making both immediate layer and sustained layer. Immediate layer with losartan potassium (LOS) was able to reduce the initial release and improve release rate by using excipient, lubricant and disintegrant. Also, sustained layer with hydrochlorothiazide (HCTZ) was able to make slow dissolution rate according to various polymer. This polymers are belong to kinds of hydrophilic polymers, which is used as mainly binder, coating agent and delayed release drug matrix. FT-IR, XRD and SEM were observed for analyzing method. Depending on several polymers as sustained layer, such drug release kinetics was represented in in vitro study respectively. As a results, the bilayer formulation used in this study can apply for complex agent. This research was supported by MIFAFF (112007-05-1-SB010) and MEST (2012M3A9C6050203). |
| 저자 |
김슬지, 양재원, 이정환, 이소진, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Bilayer; Controlled release; Losartan potassium; Hydrochlorothiazide; Physical mixture
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| E-Mail |
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