| 초록 |
Here, a bacteriophage MS2 with highly regular structure was introduced as a molecular scaffold to assemble nanoparticle into a dense and reproducible three-dimensional raspberry-shaped nanostructure. The nanostructure features an evenly-distributed electromagnetic hot-spots responsible for single molecule-level analysis of SERS-based sensing. By selecting a rigid molecular linker, as well as the selection of MS2 phage, the gold nanoparticles were able to be assembled into a deifined structure with precisely defined positions, producing strong electric near-field enhancement between nanometer-sized interparticle gaps. The numerical simulation and experimental measurement demonstrated the nano-raspberry structure produce strong SERS signal amplification, with remarkable intra- and inter-batch signal uniformity, proving structural reproducibility originated from rigid building blocks can lead to the reliable SERS measurement for molecular sensing and analysis applications. |
