| 초록 |
Bone healing is one of the important phenomena in clinical fields, including oral, maxillofacial, orthopedic and plastic surgery. The rapid appearance of fibrous connective tissue in bone defect during the healing leads to the incomplete bone formation with low mechanical strength and cartilage-like tissue. In our previous study, we developed guided bone regeneration (GBR) membranes with submicron pore sizes and hydrophilicity, which can provide good environment for bone regeneration. In this study, we applied physical (ultrasound and biological bone morphogenic protein-2,) stimulations at the asymmetrically porous PCL/Pluronic F127 GBR membrane for more enhanced bone regeneration. Their bone regeneration behaviors were compared between the stimulation groups and the control group (GBR membrane without stimulation) by histological observations. From the animal study, we recognized that the both stimulations have a positive effect on the bone regeneration through the GBR membrane. |
