| 초록 |
Recently, Graphene Oxide (GO) has attracted increasing interest for its potential of applications in biomedical fields such as biological imaging, drug/gene delivery and cancer therapy. GO has a good biocompatibility due to its many hydrophilic groups. GO has been used as a drug delivery vehicle because sp2 carbon network of GO can interact with hydrophobic drug, single nucleotide. However, to be an efficient gene delivery vector, GO should be modified with cationic polymeric gene carrier. GO is very useful for modification as it contains many hydroxyl, carboxylic acid and other reactive groups available to ligand conjugation and other modification. Polyethylenimine (PEI) has been widely used as a non-viral gene delivery vector. Therefore, we developed GO-conjugated PEI as an excellent transfecting agent. It shows high gene transfection efficiency and low cytotoxicity. Furthermoere, this conjugate exhibited remarkable photoluminescence highlighting its potential as bioimaging agent. |
