| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.460 |
| 발표분야 | 고분자 합성 |
| 제목 | Indomethacin-loaded Poly(styrene) Nanopraticles Produced by Miniemulsion Polymerization |
| 초록 | In the past 50 years, several particle nucleation mechanisms have been proposed for emulsion polymerization. Generally, emulsion polymerization was classified as three classes, i.e. microemulsion, miniemulsion, and macroemulsion. Among the emulsion, miniemulsion could be understood as aqueous dispersions of relative stable oil droplets size ranging from 30 to 500 nm prepared by intense shear of a system including oil, water, surfactant, and hydrophobe.1,2 In this work, the poly(styrene) (PS) nanoparticles containing indomethacin were synthesized by miniemulsion polymerization. The prepared PS miniemulsion were characterized by conversion, scanning electron microscopy (SEM) and particle size analyzer. As a result, the conversion rate was quickly shown in miniemulsion more than conventional emulsion. The high conversion over 90% was achieved in about 3 h. The spherical PS nanoparticles were obtained and the drug are encapsulated with PS by miniemulsion polymerization, as shown in Fig. 2. All particles shown the similar particle size, which could be attributed to the prevention of Ostwald ripening by an addition of a hydrophobe. The diameter of PS nanoparticles was adjusted between 80～160 ㎚ by homogenization and surfactant conditions.3 From the release profile of drug through UV spectra, the drug release was very slow and it could seen that the release of encapsulated drug with PS was occurred with the polymer degradation. Fig. 1. Structure of Indomethacin. Fig. 2. SEM photograph of PS nanoparticles containing indomethacin. References 1. F. Boisson, I. Uzulina, and A. Guyot, Macromol. Rapid Commun., 22, 1135 (2001). 2. K. Landfeser, F. Tiarks, H. P. Hentze, M. Antonietti, Macromol. Chem. Phys., 201, 1 (2000). 3. S. J. Park, J. R. Lee, J. Colloid Interface Sci., 219, 17 (1999). |
| 저자 | 김기석, 박수진, 이해방 |
| 소속 | 한국화학(연) |
| 키워드 | miniemulsion; poly(styrene) nanoparticle; indomethacin; hydrophobe; release profile |
