| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 |
27권 2호, p.173 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Entric Coated Mucoadhesive Xyloglucan Beads for Colon-Specific Drug Delivery |
| 초록 |
Xyloglucan, which exhibits thermally sol to gel transition, and which has the advantage of non-toxicity and low gelation concentration, is of interest in the development of sustained release vehicles. In this study, xyloglucan beads containing drug were prepared by extruding dropwise a dispersion of indomethacin in aqueous xyloglucan solution(2w/v%) through a syringe into a corn oil. The enteric coating of xyloglucan bead with EUDRAGIT L 100 was performed to achieve colon-specific drug release. Also, an adhesive force of xyloglucan was measured using the tensile test. The potential, as vehicles for colon-specific drug delivery, of the EUDRAGIT-coated xyloglucan beads formed in situ following the oral administration has been assessed by in vitro studies. As a results, drug-loaded beads were successfully prepared using xyloglucan aqueous solution and indomethacin. The size of the beads was less than 700 ㎛. The release rate of drug was reduced with the increased of the coating concentration. The entric coating of xyloglucan beads with Eudragit achieved gastroresistant and intestinal drug release.
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| 저자 |
유미경1, T.Akaike*2, M.Shirakawa**3, 조종수
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| 소속 |
1서울대, 2*Tokyo Institute of Technology, 3**Danippon Pharmaceutical Co. |
| 키워드 |
entric coating; mucoadhesive; xyloglucan; bead; colon-specific
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| E-Mail |
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