| 초록 |
In this study, we present a method for assembling biofunctionalized paper into a multiform structured scaffold system for reliable tissue regeneration using an origami-based approach. The surface of a paper was conformally modified with a poly(styrene-comaleic anhydride) layer via initiated chemical vapor deposition followed by the immobilization of poly-L-lysine (PLL) and deposition of Ca2+. Furthermore, strong adhesion of the alginate hydrogel on the paper onto the paper substrate was achieved due to an electrostatic interaction between the alginate and PLL. Also, the hydrogel-laden paper could be folded freely into 3D tissue-like structures using a simple origami based method. The cylindrically constructed paper scaffold system with chondrocytes was applied into a three-ring defect trachea in rabbits. As for the custom-built scaffold system, the hydrogel-laden paper system will provide a robust and facile method for the formation of tissues mimicking native tissue constructs. |
