| 학회 |
한국화학공학회 |
| 학술대회 |
2017년 가을 (10/25 ~ 10/27, 대전컨벤션센터) |
| 권호 |
23권 2호, p.1708 |
| 발표분야 |
생물화공 |
| 제목 |
Metabolic Engineering of Corynebacterium glutamicum for Production of 1,5-diaminopentane |
| 초록 |
The bio-based production of 1,5-diaminopentane (cadaverine) from renewable feedstock is a sustainable and promising alternative to petroleum-based chemical synthesis. A metabolically engineered Corynebacterium glutamicum to produce 1,5-diaminopentane is reported here. L-lysine decarboxylase was amplified by plasmid-based overexpression of the cadA gene under the tac promoter in an industrial L-lysine producer C. glutamicum (U2 strain). With the redesigned cadA gene, a production titer of 31.94 g/L of 1,5-diaminopentane was achieved without exogenous feeding of L-lysine by fed-batch fermentation of C. glutamicum (U2/pCEcadA). [This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science, ICT and Future Planning (MSIP) through the (NRF) of Korea (NRF-2012M1A2A2026556 and NRF-2012M1A2A2026557).] |
| 저자 |
한태희1, 조재성1, 박석현1, 이상엽2
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| 소속 |
1한국과학기술원, 2한국과학기술원 / BioInformatics Research Center |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
초록 보기 |
