화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2010년 가을 (10/07 ~ 10/08, 대구 EXCO)
권호 35권 2호
발표분야 의료용 고분자
제목 Low Molecular Weight Soluble Chitosan (LMWSC): Mechanism and Antibacterial Actions against Staphylococcus aureus
초록 We investigated the antibacterial properties of low molecular weight water-soluble chitosan (LMWSC; MW1, MW3, MW5 and MW10) using a combination of approaches, including MIC estimations at 2 different pH values, bactericidal kinetics, calcein-loaded liposomes, depolarization assay, and electron microscopy, as well as an in vivo study utilizing a wound infection and wound healing model. The antibacterial activity of LMWSC was inversely related to pH, with higher activities being observed at lower pH values. Additionally, evaluation of the effect of antibacterial concentrations of LMWSC on the morphology of Bacillus megaterium and Escherichia coli O-157 revealed that it induces filamentation. This study was supported by IPET(Korea Institute of planning & Evaluation for Technology in Food, Agriculture, Forestry & Fisheries) Research Fund in 2009.
저자 나재운1, 박윤경2
소속 1순천대, 2조선대
키워드 LMWSC; Antibacterial Action; Staphylococcus aureus
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