| 초록 |
Stent is an essential medical device to prolong survival when plaque blocks body conduits. However, a conventional bare-metal stent (BMS) has been faced with restenosis problem caused by tissue hyperplasia secondary to BMS placements. Drug-eluting stent (DES) has been introduced to lower rate of restenosis. Especially reservoir-based DES has attracted lots of attention due to advantages of high capacity of drugs. In addition to DES, to treat restenosis, controlling the cell behavior that interact with implanted devices has been also considered as desirable strategy because there is a need to limit the adhesion of cells on stent. In order to effectively inhibit restenosis, we suggest multifunctional DES combined physically cell repellent approach with drug treatment using nanoturf structure. An ultraviolet (UV)-curable polysiloxane acrylate (PSA) is used to fabricate multifunctional nanostructure using two consecutive steps: UV induced polymerization and reactive ion etching. We elucidate tumor cell repellent property by showing reduced focal adhesion and monitoring number of attached tumor cells. Furthermore, we showed localized drug elution via near-infrared (NIR) irradiation. |
