| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Biomimetic surface modification of poly (L-lactide-co-ε-caprolatone) with gelatin using 60Co γ-ray irradiation |
| 초록 |
The overall goal of this study is to develop an elastic biomimetic substrate that is capable of eliciting cellular response for tissue engineering. Gelatin was covalently coupled to poly (acrylic acid) (PAAc) that was grafted on the surface of poly (L-lactide-co-ε-caprolatone) (PLCL) films using 60Co γ-ray irradiation. The properties of PLCL, PLCL-AAc, and PLCL-AAc-gelatin films were investigated by ATR, ESCA, and Instron. To examine cellular response to the gelatin-grafted film, NIH3T3 cells were cultured on each film, showing that significant increase in attachment on the gelatin-grafted film than PLCL film. Cells on the gelatin-grafted film spread to all directions while cells on the others did not spread, maintaining circular shape after fluorescent staining. These results indicate that the surface modification using γ-ray is a novel technique to make biomimetic material directing desirable cellular responses, which may provide a powerful source for designing scaffolds. |
| 저자 |
신영민1, 정성인1, 임윤묵2, 노영창2, 이영무1, 신흥수1
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| 소속 |
1한양대, 2원자력(연) |
| 키워드 |
Biomimetics; Surface modification; Irradiation; PLCL; Gelatin
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| E-Mail |
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