| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
International Symposium on Advanced Biopolymers (의료용 고분자 부문위원회, 영어발표) |
| 제목 |
Light/ROS-responsive Nanovesicles for Anticancer and Anti-inflammation Therapy |
| 초록 |
External or internal stimuli-responsive drug delivery systems have been of great interest in that drug molecules are to be released to the site of a disease in a controlled manner, thereby improving efficacy but minimizing toxicity. Here we report a dual light/ROS stimuli-responsive bilirubin nanovesicles (BNVs) for potential anticancer and anti-inflammation therapy. Bilirubin is a final metabolite of heme and functions as a potent antioxidant by scavenging ROS in our body. More interestingly, bilirubin can undergo photo-mediated isomerization to more water-soluble compounds. To use bilirubin for biomedical applications, it was first converted to pegylated bilirubin, which undergoes self-assembly to yield uniform nanovesicles with size of ~120 nm. In this lecture, preparation, characterization, and stimuli-induced disruption behavior of BNVs will be presented. Furthermore, as proof-of-concept, therapeutic efficacy of BNVs on a mouse colitis model will be also presented. |
| 저자 |
Sangyong Jon1, Younghyun Lee2, Soyoung Lee3
|
| 소속 |
1KAIST Institute for the BioCentury, 2Department of Biological Sciences, 3Korea Advanced Institute of Science and Technology |
| 키워드 |
drug delivery; light/ROS responsive; nanovesicle
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| E-Mail |
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