| 초록 |
Poly(vinyl alcohol) (PVA) hydrogel having good biocompatibility, mechanical properties and high water content has been widely utilized for wound dressing, drug carrier and bulking agent (or filler). PVA hydrogels have usually produced by chemical (using crosslinkers) or physical (using freeze-thawing technique) crosslinking of PVA chains. However, the residual toxic crosslinking agents in the hydrogel and long processing time are considered as practical limitations. In this study, we developed a novel PVA hydrogel fabrication technique which does not need any toxic crosslinking agents and does not include time-consuming steps for hydrogel formation by a simple quenching procedure. The crystallinity (by x-ray diffraction), mechanical properties (using Instron), and stability in the PBS of the prepared PVA hydrogels were characterized. |
