| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vitro study to the biocompatibility of poly(vinyl alcohol) hydrogel for Articular Cartilage Replacement |
| 초록 |
Poly(vinyl alcohol) (PVA) have been proposed as promising biomaterials to replace diseased or damaged articular cartilage. Biodegradable polymers are limited by poor bioactivity, weak mechanical properties, and inflammation produced by acidic byproducts. Otherwise, Non-degradable PVA hydrogel is a hydrophilic, biocompatible and transparent hydrogel with physical strength gives a rise to the material for an articular cartilage replacement. A porous structure with well inter-connected pores is required not only to achieve sufficient cell seeding density within the scaffold, but also to facilitate transport of nutrients and oxygen for subsequent cell proliferation and differentiation. This study aims at the new fabrication method of porous PVA Hydrogel(PVA) and immobilization of type I collagen(Col) onto PVA (PVA-Col) to improve cell seeding density, adhesion, viability, and proliferation of chondrocyte. |
| 저자 |
정홍희1, 최연락2, 장주웅2, 심영복2, 이광일2
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| 소속 |
1네온메디칼, 2코리아본뱅크 |
| 키워드 |
Poly(vinyl alcohol); articular cartilage; type I collagen
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| E-Mail |
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