| 초록 |
Multiplexing of molecules with high sensitivity and selectivity is an essential technology in clinical diagnostics and environmental monitoring. So far, various biosensing assays based on fluorescence and electrochemical response have been developed for this purpose. However, limitations in resolution and lack in specificity are issues yet to be overcome. Surface-enhanced Raman spectroscopy (SERS) techniques have drawn much attention for sensor applications due to its single-molecule level sensitivity. In this study, we propose a sensor based on aptamer-functionalized SERS for improved selectivity in multiplexing operations of drinking water pollutants. XPS analysis confirm immobilization of aptamers onto Au nanostructures. Singular and multiplex Raman spectra exhibit successful detection of target molecules, and tests under mixed solutions show promising results for applications in the real environment. |
