| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
PVP Molecular Effect on the Dissolution Property of Solid Dispersion of Carvedilol |
| 초록 |
This study aimed to confirm the effect of molecular weight in solid dispersion of carvedilol with polyvinylpyrrolidone (PVP) of various molecular weight (PVP K-17, K-25, K-30). Solid dispersion of carvedilol with PVP was prepared by spray-drying method. Scanning electron microscopy (SEM) was used to analyze the surface of solid dispersion samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystalline of solid dispersion. Fourier transform infrared spectroscopy (FT-IR) was used to analyze the change of chemical structure characteristic of solid dispersion. The dissolution studies of solid dispersion presented at simulated gastric juice (pH 1.2). The dissolution rate of solid dispersion was dramatically enhanced than pure drug and the molecular weight of PVP has an effect on the release property of carvedilol in solid dispersion. This research was supported by WCU (R31-20029). |
| 저자 |
심정보, 김형석, 조한수, 이소진, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
carvedilol; solid dispersion; PVP; molecular weight
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| E-Mail |
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