| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Delivery of antisense oligonucleotides using PEI-coated gold nanoparticles for targeting multidrug-resistant bacteria |
| 초록 |
Infectious diseases caused by multidrug-resistant bacteria have been a major cause of mortality worldwide. The spread of bacterial infections due to the overuse of broad-spectrum antibiotics has emerged as a serious and urgent public health problem. In particular, methicillin-resistant Staphylococcus aureus (MRSA) has developed antibiotic resistance genes that are responsible for its virulence. Nanoparticle-based gene delivery systems that inhibit the expression of target genes provide an alternative treatment option for combating multidrug-resistant bacterial infections with high selectivity. PEI-coated gold nanoparticles loaded with antisense oligonucleotides targeting the mecA gene were efficiently taken up into MRSA that resulted in inhibition of bacterial growth in presence of oxacillin. This study presents a novel application of gene delivery systems in the treatment of multidrug-resistant bacterial infections that can overcome limitations of conventional antibiotics. |
| 저자 |
Marcel Janis Beha, 정현정
|
| 소속 |
KAIST |
| 키워드 |
Nanoparticle-based drug delivery; gene silencing; multidrug-resistant bacteria
|
| E-Mail |
|
