| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Anti-SenescenceIon-Delivering Nanocarrier for improving Therapeutic Properties of high passage HumanAdipose-Derived Stem Cells |
| 초록 | Human adipose-derived stem cells (hADSCs) have been usedin various fields of tissue engineering because of their promising therapeuticefficacy. However, the stemness of hADSCs cannot be maintained for longdurations, and their therapeutic cellular functions, such as paracrine factorsecretion decrease during long-term cell culture. To facilitate the use of long-term-culturedhADSCs (L-ADSCs),we designed a novel therapeutic anti-senescence ion-delivering nanocarrier(AIN) that is capable of recovering the therapeutic properties of L-ADSCs. Inthe present study, we introduced a low-pH-responsive ion nanocarrier capable of delivering transition metal ions that can enhance angiogenic paracrinefactor secretion from L-ADSCs. The AINs were delivered to L-ADSCs in anintracellular manner through endocytosis. |
| 저자 | 현지유, 방석호 |
| 소속 | 성균관대 |
| 키워드 | Angiogenesis; functionality restoring; intracellular ion delivery; ischemic disease; senescence; stem cell therapy |
