| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 봄 (05/13 ~ 05/14, 충남대학교) |
| 권호 |
9권 1호 |
| 발표분야 |
정밀화학 |
| 제목 |
Microwave-assisted Hydrolysis of Esters by Silica gel under Solvent-free Conditions |
| 초록 |
Various esters are commonly used in the synthesis of peptides, alkaloids and other natural products and substrates of medicinal interest. Removal of esters often involves the use of strong protic acids such as trifluoroacetic acid and hydrochloric acid, or Lewis acid such as zinc bromide and silyl triflates. These vigorous conditions can often lead to unwanted side reactions and decomposition of sensitive substrates. Herein we report a microwave-assisted hydrolysis method using silica gel as an efficient reagent for the cleavage of esters without solvents. These mild cleavage conditions broadens the synthetic applications in which protected carboxylates can be utilized.
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| 저자 |
박두한, 김준범, 김혜경
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| 소속 |
삼육대 |
| 키워드 |
Microwave-assisted; solvent-free; Hydrolysis
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| E-Mail |
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