| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Electrospinning of PET/chitosan nanofibrous scaffolds showing antibacterial activities |
| 초록 | [Introduction] Nanofibers produced by electrospinning have significantly large surface area to volume ratio, porosity, surface functionalities, and superior mechanical properties1. These remarkable properties underlie the substantial interests in these materials for industrial, biomedical, and electronic applications2. Polyethylene terephthalate (PET) shows the excellent properties like transparency, outstanding processability, light weight, and good impact resistance. Chitin and chitosan were employed to improve antibacterial activities and biocompatibility of PET matrices3. [Experimental] For electrospinning, PET/chitosan and PET/chitin were dissolved in trifluoroacetic acid and hexafluoropropanol, respectively. The nanofibers were deposited on the PET micro nonwoven sheets. The antibacterial effect of PET/chitosan blended nanofibers on Staphylococcus aures and Klebsiella pneumoniae was performed by the static vial methods. And to assay cell behaviors on nanofibers, the attachment and proliferation of cells on the surface was studied using fibroblasts. [Results and Discussion] PET/ chitosan and PET/chitin solution were electrospun to obtain nanosized fibers(Fig. 1.). From antibacterial tests using the static method, the electrospun PET blended with 10 wt% chitosan showed over 90% of growth inhibition rate while PET blended with 10 wt% chitin showed around 50%. And fibroblasts were well attached and proliferated on PET/chitosan and PET/chitin nanofibers. Fig. 1. SEM views of nonwoven nanofiber mats; (a) PET/chitin, (b) PET/chitosan [References] 1. Frenot, A.; Chronakis, I.S. COCIS 2003, 8, 64. 2. Nair, L.S.; Bhattacharyya, S.; Bender, J.D.; Greish, Y.E.; Brown, P.W.; Allcock, H.R.; Laurencin, C.T. Biomacromolecules 2004, 5, 2212. 3. Koide, S. S. Nutri. Res. 1998, 18, 1091. 4. Sashiwa, H.; Aiba, S. Progress in Polym. Sci. 2004, 29, 887. |
| 저자 | 정경혜, 강인규, 현석희 |
| 소속 | 경북대 |
| 키워드 | nanofibers; chitosan; antibacterial activity |
