| 초록 |
Acne is a skin disease that affect not only in adolescents but also adults. Propionibacterium acnes (P. acnes) is a major pathogen of acne. Antibiotics are used to treat acne, but they cause side effects such as antibiotic-resistance due to excessive dose. In this study, enzyme-responsive transfersomes (ERT) which has an antibacterial photodynamic therapeutic effect for P. acnes. The addition of a surfactant as an edge activator increases the skin permeability of ERT. The photoactivity of ERT is restored by the enzyme-specific reaction of P. acnes esterase to the ester bond of ERT lipid. The selective photoactivity against P. acnes in vitro indicate excellent antibacterial effect. Also, in vivo antimicrobial effect of ERT is confirmed by a volume of skin-inflammation caused by P. acnes on the back of mouse. These results demonstrate that the photodynamic therapy with ERT has an excellent antimicrobial effect and potential as a therapeutic agent to replace antibiotics |
