| 초록 |
Flavonols, natural polyphenolic compounds found in a variety of plant-based foods have been extensively studied for their antioxidant, anticancer and antiviral activities. However, their translation into clinical practice has been hampered by an inherent poor bioavailability, instability and poor targeting. Therefore, strategies for conjugating such flavonols with functional groups through cleavable linkages which can improve their properties have been of great interests among researchers. Here, we represent our efforts for finding optimal pH and buffer conditions of conjugating several flavonols with solid-phase phenylboronic acid derivatives. In addition, we determined the hydrolysis conditions of phenylboronic esters derivatives back to the phenylboronic acid derivatives and the flavonols. |
