| 초록 |
Spatial networks of natural extracellular matrix (ECM) fibers are closely related to tissue phenotypes, cellular differentiation and proliferation, soluble factor secretion, and other important biochemical signaling processes. Strategies for mimicking the fibrous morphology of the ECM can serve as a valuable platform for creating a favorable environment that effectively manipulates cellular behaviors. Electrospinning is a representative methodology that can be used to artificially construct fibrous networks; the resulting electrospun fibrous constructs have served as powerful templates in many biomedical fields to complement the key functions of the natural ECM. Therefore, several high-impact studies have proposed smart technologies that significantly improved the technical aspects of electrospun fibers. Finally, a powerful technology capable of tuning gene delivery via viral vectors, adeno-associated viral (AAV) vectors, will be introduced along with the electrospinning techniques. |
