| 초록 |
Stimuli-responsive degradable hydrogels have been widely used as advanced materials in diverse biomedical applications. Enzymes play a crucial role in physiological processes and their expression level alters in a wide variety of diseases and pathological disorders. Therefore, enzymes can be a biological trigger to control the appropriate degradation rate of bioactive hydrogel and to achieve a controlled release of therapeutic substances at specific sites. To control the release rate of the drug, here we designed a micropatterned hydrogel that contains a peptide crosslinker and methacrylated hyaluronic acid (meHA), an anti-cancer drug carrier. We used H-Cys-Tyr-Lys-Cys-OH (CYKC) peptide sequence which is cleaved in response to α-chymotrypsin. We expect these strategies can be a promising controlled drug delivery system in the future. |
