| 초록 |
Bone tissue regeneration is one of the key challenges in biological applications. In this study, we approached a conceptual platform that can integrate stem cells into a multiscale patterned substrate for bone regeneration. Inspired by human bone tissue, we developed hierarchically micro- and nanopatterned transplantable patches using a poly(lactic-co-glycolic acid)(PLGA) polymer. The multiscale patterned PLGA patches were highly flexible and showed higher tissue adhesion. In response to the multiscale patterned topography, the adhesion and differentiation of human mesenchymal stem cells (hMSCs) were sensitively controlled. Furthermore, the prepared stem cell patches promoted bone regeneration when both the micro- and nanotopography were synergistically combined. Thus, our study concludes that multiscale patterned transplantable stem cell patches may have a great potential for bone regeneration as well as for various regenerative medicine approaches. |
