| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and characterization of Dextran-Spermine-gCB polymer as a efficient targeted gene carrier. |
| 초록 |
Dextran, a biodegradable natural polysaccharide has been modified with cationic oligoamine, spermine as a non-viral polymeric gene carrier. In this study, D-spm which is a cationic polysaccharide based on spermine-dextran was successfully synthesized by chemical modification after reductive amination. In addition, glactosyl conjugated cucurbituril(galCB) was bound into the cationic polysacchardes via host-guest interaction of D-spm and galCB bridge to exhibit higher cell specific-targeting efficiency simultaneously. The formation and substitution degree of oligoamines on D-spm/galCB were confirmed by NMR, IR and elemental analysis. The physicochemical properties of D-spm/galCB were evaluated by particle size measurement and zeta potential assay. Also, the transfection efficiency and cytototixity of modified dextran were investigated in HepG2 cell containing hepatocyte receptor and HeLa cell, not containing it. |
| 저자 |
김수경1, 박경민1, 최지숙2, 김기문1, 김원종1
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| 소속 |
1포항공과대, 2강원대 |
| 키워드 |
dextran; cucurbituril; specific targeting; polymeric gene carrier
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| E-Mail |
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