| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Photosensitizer-conjugated Magnetic Iron Oxide/Gold (Core/Shell) Nanoparticle as a Platform for Controllable Photodynamic Cancer Therapy |
| 초록 |
A core/shell structured magnetic iron oxide/gold (Fe3O4/Au) nanoparticle (NP) is investigated as a novel photosensitizer carrier for photodynamic therapy (PDT). A thiolated heparin-pheophorbide a conjugate (H-PhA) is synthesized and introduced onto the NP surface through gold-thiol interaction. Fe3O4/Au NP can act as a quenchable nanocarrier for H-PhA conjugate, whereas glutathione can mediate the H-PhA release in a photoactive form. In vitro and in vivo studies show that Fe3O4/Au/H-PhA NPs are effective for PDT due to the prolonged circulation characteristic, enhanced tumor specificity, and the controlled photoactivity. In addition, in vitro MRI studies reveal that the NPs could potentially serve as MRI contrast agent for cancer diagnosis, and monitor photodynamic treatment response for guiding accurate light irradiation. The present findings show that the Fe3O4/Au/H-PhA NP is a promising nanomedicine for cancer theranosis. |
| 저자 |
이립1, Md Nurunnabi2, Md Nafiujjaman2, 정용연3, 이용규2, 허강무1
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| 소속 |
1충남대, 2한국교통대, 3전남대 |
| 키워드 |
hybrid nanoparticle; controllable photoactivity; magnetic materials; photosensitizer; photodynamic cancer therapy
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| E-Mail |
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