| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
pH-Sensitive Calcium Carbonate Mineralized Nanoparticles for Effective Photodynamic Therapy |
| 초록 |
In this study, we demonstrated the potential of calcium carbonate (CaCO3) mineralized hybrid nanoparticles for photodynamic therapy. Poly(ethylene glycol)–poly(L-aspartic acid) (PEG-PAsp) can act as a nanotemplate and participate in the formation of the CaCO3 core due to the anionic carboxylates of PAsp. Besides, the hydrophilic photosensitizer (PS), chlorin e6 (Ce6), can be trapped in CaCO3 core of particles. The nontoxic CaCO3 mineral core allowed the facilitated release of entrapped Ce6 within the acidic intracellular compartments (pH 5.0) such as endosomes and lysosomes. Therefore, this nanoparticle showed the potential not only for minimizing Ce6 loss in blood but also for selective release of Ce6 within cells after tumor targeting. CaCO3 mineralized hybrid nanoparticle seems very promising as an ‘on demand’ nanocarrier system for effective photodynamic therapy. We anticipate the potential advantage for future in vivo and clinical application. |
| 저자 |
박동진, 민경현, 구안나, 이홍재, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
pH-sensitive; Nanoparticles; Mineralization; PDT
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| E-Mail |
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