| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and controlled photoactivity of photosensitizer conjugated heparin-gold nanoparticle for photodynamic therapy |
| 초록 |
In this study, a novel pheophorbide a-conjugated hybrid nanoparticle with controllable photoactivity was design and synthesized. Pheophorbide a-conjugated heparin (PhA-H) was synthesized to encapsulate AuNP through gold-thiol interaction. Due to the strong fluorescence quenching effect of AuNP, the photoactivity of PhA-H/AuNP could be effectively prevented in physiological conditions. However, the photoactivity of PhA-H/AuNP could be restored by GSH-mediated intracellular dissociation of PhA-H molecules from AuNP. In vitro cell studies revealed that the PhA-H/AuNP could release the PhA-H molecules in photoactive form after cellular uptake and could generate singlet oxygen with light irradiation. Furthermore, PhA-H/AuNP presented prolonged blood circulation, enhanced tumor specificity, and improved therapeutic efficacy compared to free PhA as studied on tumor-bearing mice. These finding indicated PhA-H/AuNP could be used as safe and smart nanomedicine for clinical PDT. |
| 저자 |
이립1, Md. Nurunnabi2, Md. Nafiujjaman2, 이용규2, 허강무1
|
| 소속 |
1Chungnam National Univ., 2Korean Univ. of Transportation |
| 키워드 |
pheophorbide a; heparin; gold nanoparticle
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| E-Mail |
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