| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Ni(II) Arsenite-Complexed Poly(L-DOPA) Core-Containing Polymer Nanoparticles for Cancer Treatment |
| 초록 |
Arsenic trioxide (ATO) is high cytotoxicity to various types of cancer cells and lower risk of recurrence and metastasis. However, it has short half-life and dose-limiting toxicity. Nonetheless, these disadvantage could be resolved by employing nanocarrier systems incorporated with a transitional metal-arsenite complex. Herein, we developed a self-assembled poly(ethylene glycol)-b-poly(L-dihydroxyphenylalanine) (PEG-P(L-DOPA)) nanoparticle that formed Ni(II) arsenite complexes on the P(L-DOPA) core domain. The Ni(II) arsenite complexes would effectively improve the structural stability of PEG-P(L-DOPA) nanoparticle in an aqueous phase. The release of arsenite would be inhibited at physiological pH (7.4), whereas, at an endosomal pH (~5.0), the release of arsenite was triggered by ionization of the Ni(II) arsenite complexes. This novel polymer nanoparticle containing Ni(II)-chelating P(L-DOPA) cores would enable the stable loading and effective intracellular delivery of As(Ⅲ). |
| 저자 |
최정렬, 김다은, 남혜영, 이홍재, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
Nickel; Arsenite trioxide; catechol group; nanoparticles
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| E-Mail |
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