| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-나노 |
| 제목 |
Synergistic Photo Cancer Therapy using NIR-triggered Anisotropic Gold Nanobipyramids/Anatase TiO2 photocatalyst |
| 초록 |
Anatase titania (aTiO2) coated gold nanoclusters are hard to applied for cancer therapy due to their aggregation issue and morphological disruption of gold during amorphous TiO2 phase changes. Herein, we share a novel methodology to coat aTiO2 onto gold nanobipyramids (Au NBP) at low temperature ranges. The resulting well-defined Au NBP/aTiO2 structures retained their morphology and sharp metal tips responsible for strong electric fields. Preliminary catalytic activity results demonstrated the generation of reactive oxygen species under laser irradiation, sustaining an injection of LSPR-induced hot electrons onto the TiO2 conduction band, for which the well-preserved sharp gold tip and clear monodispersity of our materials played a critical role. Au NBP/aTiO2 uncovered superior results for cancer therapy ascribed to their high uptake rate by human glioblastoma, biocompatibility assessed under dark conditions, and, most importantly, photothermal and photodynamic dual therapeutic effect. |
| 저자 |
장도협1, 유수빈2, 안동준3, 김세훈1, 김동하2
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| 소속 |
1한국과학기술(연), 2이화여자대, 3고려대 |
| 키워드 |
Gold nanobipyramids; Photo cancer therapy; anatase titanium dioxide
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| E-Mail |
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