| 초록 |
Many methods to control the release rate of proteins have been developed to engineer the release rate, but generally produce protein carriers having the initial burst release and unstable protein structures. Recently, electrohydrodynamic jetting has been recognized as an alternative method to satisfy these properties. In this study, immiscible co-axial electrohydrodynamic jetting was used to fabricate the core/shell protein carriers. Water-immiscible poly(lactic-co-glycolic acid) solutions and protein (lysozyme) aqueous solutions were utilized as the outer fluid and the inner fluid, respectively. The pores in/on the shell are formed by controlling the removal rate of volatile solvents. To tailor the core/shell carriers of various release rate, polyacrylic acid and chitosan were co-incorporated with lysozyme in the core. The electrostatic interaction effectively affects the control of release rate of lysozyme. |
