| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
고분자구조 및 물성 |
| 제목 |
In vivo immunostimulation using CpG-loaded DNA nanoparticles |
| 초록 |
We introduce a versatile carrier system based on DNA nanoparticles (NPs). Incorporation of lipid-modified nucleobases to DNA strands enables formation of micelles in uniform size. In a single self-assembly step the micelles can be equipped with immune adjuvant (CpG) and fluorescent probe through Watson-Crick base-pairing. With the NPs we have investigated effect of the CpG concentration in immunostimulation. We observed dose dependent activation of TLR-9 resulting in DC maturation in vivo. |
| 저자 |
곽민석, 박해인
|
| 소속 |
부경대 |
| 키워드 |
micelle; immunology
|
| E-Mail |
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