| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.327 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Elastic biocompatible poly(L-lactide-co-ε-carprolactone) for cartilage tissue engineering |
| 초록 |
Cartilage is always under the influence of compressive forces by weight. That means compressive mechanical stimuli are very important factor in tissue engineering of regenerative cartilage. So it is likely to be necessary the development of scaffolds which can maintain their mechanical integrity and delivers the mechanical signals to adherent cells during mechanical strain application. The objective of this study is to develop mechano-active scaffolds which are elastic and capable of withstanding cyclic mechanical strain without cracking or significant permanent deformation. Biodegradable poly(L-lactide-co-ε-carprolactone) copolymer was synthesized from lactide and e-caprolactone in the presence of stannous octoate as catalyst. The scaffolds with 80% and 90% porosity and 300~500mm pore size were fabricated by gel-pressing method. Tensile mechanical tests and recovery tests were performed in a dry condition and dynamic mechanical tests were measured in vitro condition. Also, for examining cartilage tissue formation, chondrocytes from rabbit cartilages were seeded on scaffolds and cultured for 5weeks. Cell/polymer constructs were characterized by GAG and collagen quantitative analysis. This study shows that permanent deformations of scaffolds were less than 5% of the applied stain and cartilage tissue formation was developed. The elastic PLCL scaffolds could be used to engineer cartilage in mechanically dynamic environments. |
| 저자 |
유희진, 정영미, 김영하, 김수현
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| 소속 |
한국과학기술(연) |
| 키워드 |
poly(L-lactide-co-ε-carprolactone); elastic polymer scaffolds; cyclic strain; cartilage tissue engineering
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| E-Mail |
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