| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effects of sustained-release Tulobuterol on Asthma control from granule delivery system |
| 초록 | Granule system which is one of the drug delivery system has been developed to improve manufacturing process and other problems of tablet osmotic system. It consists of seed layer, drug layer, and drug release controlled membrane layer and manufactured by fluidized bed coater. Tulobuterol(α-〔(tert-butylamino)methyl〕benzyl alcohol) hydrochloride is a novel bronchodilator; as one of the β2-agonist agents, it has superior selective activity on the β2-receptor than other agents in this class. Recently, Eudragit acrylic resins have been widely used in the pharmaceutical industry as a film coating for bitter taste prevention and controlled drug delivery. We studyed the effects on the in vitro release profiles of tulobuterol hydrochloride granule coated with an Eudragit film-coating formulation. Fig 1. The effect of differnet membrane thickness of tulobuterol bead on release profile at pH 1.2 Acknowledgement : This work was supported by KMOCIE (10016551). Reference 1. G. Khang, J. M. Rhee, and H. B. Lee, "Drug Delivery System Using Osmotic Pump", in High Efficiency Anticancer Drug Using Polymeric Biomaterials, H. B. Lee, Editor, Munundang Publishing Co., Seoul, Chap. 10, pp 135~154 (2004) 2. H. B. Lee, D. H. Lee, B. K. Kang, S. Y. Jeung, and G. Khang, J. Korean Pharm. Sci., 32, 241 (2002). |
| 저자 | 서성미1, 이현숙2, 서진아2, 이봉3, 강길선4, 이해방5, 조선행5 |
| 소속 | 1부경대 / 한국화학(연), 2한남대, 3부경대, 4전북대, 5한국화학(연) |
| 키워드 | Tulobuterol HCl; granule; Eudragit |
