| 초록 |
Blue marine mussel (Mytilus edulis) byssal threads are covered with granular morphology cuticles, which are cross-linked by both covalent bonds and metal coordination bonds. Chitosan was modified with multiple catechol groups to mimic the mussel adhesive proteins containing an unusual amino acid, L-3,4-dihydroxy-L-phenylalanine (DOPA), which is particularly abundant in the interface between adhesive pads and opposing surfaces. Bio-inspired by byssal cuticle chemistry, the covalent bonded catechol-functionalized chitosan/thiolated Pluronic hydrogels and the iron-coordinated catechol-functionalized chitosan hydrogels were synthesized for hemostatic materials and tissue adhesives. These chitosan-based hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and anti-bleeding materials. |
