| 초록 |
Nitric oxide (NO) gas has many potentials to be applied in physiological systems. It is an imperative cell signaling molecule which performs vasodilation, immune suppression, anti-cancer, wound healing and so forth. In this respect, NO delivery systems have been extensively developed in these days. Most of all, release control of NO is essential because NO can result in different physiological responses depending on its concentration. To overcome fast diffusion characteristics of gas, in this study, we developed NO delivery carriers using polymeric films. Branched polyethylene imine (BPEI) is a good reservoir of NO donors because many amine groups of BPEI generate N-diazeniumdiolate –NO donor– and stabilize it by molecular interaction. By using this, we developed nanoparticles and two-dimensional surface based on BPEI films which release NO in a controlled manner. Further, possibility of these platforms in biomedical applications was examined by cell and animal studies. |
