| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlled Release of Drugs from Nanoparticles Made of pH-Sensitive Polymer |
| 초록 |
To date pH-sensitive polymers have been widely used in the fields of drug delivery. Drug-encapsulated nano particles made of pH-sensitive polymers have shown their potential for use in drug delivery vehicles targeting to cancers or antigen presenting cells (APCs). The highly increased drug release at mild acidic condition (~pH 5-6) compared to extracellular pH 7.4 render them be useful for such purpose. In this work we synthesized a pH-sensitive polymer, poly(tetrahydrofuranyl methacrylate) ; poly(THPMA) and examined the feasibility of the polymer as drug delivery vehicle in the form of drug-encapsulated nanoparticles. The size and zeta potential of the drug-contained nanoparticles was measured using ELS. Drug release study was done using rhodamine B as a model drug at two different pH conditions: pH 5.1 acetate and pH 7.4 HEPES buffer. The details with respect to synthesis of poly(THPMA) and characterization and drug release profiles of the nanoparticles will be presented. |
| 저자 |
정주아, 전상용
|
| 소속 |
광주과학기술원 |
| 키워드 |
pH sensitive polymer; controlled release; drug delivery
|
| E-Mail |
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