| 초록 |
There is growing interest in theranostic nanomedicine with integrated imaging and therapeutic modalities for simultaneous diagnosis, disease treatment, and monitoring of therapeutic efficacy. Especially, surface-enhanced Raman scattering (SERS) technology based on gold nanostructures has been recognized as an alternative to QD-based fluorescence imaging method because gold nanoparticles can induce enhancement of the Raman signal, narrow the Raman peak width more than fluorescence peaks, and little photobleaching effect. In this study we developed a novel SERS probe based on gold nanochains (AuNCs) for imaging and photodynamic therapy (PDT) of cancer cells. Raman reporter and photosensitizers were conjugated onto AuNCs by thiol groups, and then the optical property and morphology of AuNCs were evaluated. We also investigated their biocompatibility, cellular localization property, and phototoxicity against HeLa cells. |
