| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Tumor-Targeting SERS Probe for Multiplex Detection and photodynamic therapy of Cancer |
| 초록 |
Highly sensitive optical imaging technology using metal nanoparticles has been extensively applied to cellular imaging and biomedical diagnostics. Surface-enhanced Raman scattering (SERS) as the inelastic light scattering of gold or silver nanoparticles is emerging as a powerful alternative for identifying specific biological targets in live cells. In this study, we synthesized novel gold nanochains (AuNCs) as an active targeting SERS probe. Raman reporters and photosensitizers (PSs) were conjugated onto the surface of the AuNCs for multiplex detection and PDT action. FA was also introduced to the AuNCs for active targeting. The optical property and morphology of HA-based AuNCs were determined. We also investigated their biocompatibility, cellular localization property, and phototoxicity against MCF 7 and A549 cells. |
| 저자 |
김소연, 최종선, 자오린린
|
| 소속 |
충남대 |
| 키워드 |
SERS; nanoparticle; PDT; cancer
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| E-Mail |
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