| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Effect of surface modified magnesium hydroxide on mechanical and biological properties of poly(L-lactic acid) based composite |
| 초록 |
Poly(L-lactic acid)(PLLA) has been widely used in biomedical applications such as vascular stents due to good biocompatibility. Magnesium hydroxide(MH) can improve mechanical properties of polymer matrix and alleviate inflammation by neutralizing pH during hydrolytic degradation. However, the MH particles easily agglomerate together, resulting in poor dispersion of MH particles in the polymer matrix. In this work, surface-modified MH(m-MH) was developed to improve mechanical and biological properties of PLLA more effectively. The PLLA composites were confirmed by FTIR, TGA, tensile testing, SEM, and pH measurements. In addition, the cytotoxicity and inflammatory response of both human coronary artery endothelial(HCAEC) and smooth muscle cells(HCASMC) were evaluated by CCK-8 and IL-6/IL-8 production, respectively. The results showed that the PLLA/m-MH composites demonstrated not only the higher mechanical performance but also better biocompatibility compared to PLLA/MH composites. |
| 저자 |
한동근1, 강은영1, 한철민2, 강종희3, 김익환3, 정윤기2
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| 소속 |
1차의과학대, 2고려대, 3한국과학기술(연) |
| 키워드 |
PLLA; magnesium hydroxide; surface modification; nanocomposite
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| E-Mail |
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