| 초록 |
This study was conducted to evaluate physiological activity of Robinia pseudo-acacia leaf and its skin penetration using polymer micelles and skin penetrating peptide. DPPH radical scavenging ability, Elastase inhibitory assay, SOD-like activity, and Tyrosinase inhibitory activity except total polyphenol content showed that Robinia pseudo-acacia leaf ethanol extract was higher than that of the Robinia pseudo acacia leaf hydrothermal extract at all concentrations. In the antimicrobial experiments, the hydrothermal extract had no effect, but ethanol extract represented clear zone in Propionbacterium acnes strain and Bacillus subtilis strain. To solve the problem of insolubility and to improve skin penetration, PCL-PEG polymer micelles containing Robinia pseudo-acacia leaf ethanol extracts and 1% cell permeable peptide, hexa-D-arginine (R6) were successfully prepared with particle size of 108.23 and 126.47 nm and excellent skin permeation effects could be showed. |
