| 초록 |
Stimuli-responsive hydrogels that exhibit volume changes in response to environmental changes such as pH and temperature have many future opportunities as suitable materials for designing smart systems in biomedical fields. We have prepared a variety of biomolecule-responsive hydrogels by using biomolecular complexes as reversible crosslinks. This paper describes two types of biomolecule-responsive hydrogels that undergo volume changes in response to target biomolecules, which were prepared using biomolecular complexes such as antigen-antibody complexes and saccharide-lectin complexes. One is a biomolecule-crosslinked hydrogel that can swell in response to a target biomolecule and the other is a biomolecule-imprinted hydrogel that can shrink. For example, the antigen-responsive hydrogels as biomolecule-crosslinked hydrogels swelled in the presence of a target antigen due to the dissociation of antigen-antibody complexes that played a role as reversible crosslinks. On the other hand, the tumor marker glycoprotein-responsive hydrogels as biomolecule-imprinted hydrogels shrank in response to a target glycoprotein due to the complex formation between ligands (lectin and antibody) and the target glycoprotein. Thus, biomolecule-responsive hydrogels have many potential applications as smart biomaterials in biomedical fields. This paper focuses on synthetic strategy of biomolecule-responsive hydrogels and their responsive behavior. |
