| 초록 |
Stimulus responsive hydrogels present the potential to exhibit reversible volumetric changes in response to external stimuli including pH, electric current, temperature and ionic strength. Therefore, these hydrogels have been studied for various applications including controlled drug delivery, tissue engineering, microscale actuators and microfluidic flow control. This study demonstrates that a new method to align and control spatial organization of bioactive hydrogel into microchannels of a poly(vinylidene fluoride) membrane and guide growth direction and spacing of living cells. This integrated bioactive hydrogel system was prepared by fabricating a micro-channeled PVDF membranes and subsequently filling micro-channels with a hydrogel of chemically active methacrylic alginate. We believe that the integrated bioactive hydrogel membrane developed in this study will be highly useful for a broad array of drug delivery carriers in varied applications. |
