| 초록 |
A terpolymeric hydrogel was prepared by grafting of 2-hydroxyethyl acrylate onto hyaluronate via free radical polymerization, and crosslinking using poly(ethylene glycol) diacrylate. The developed terpolymer was characterized by diverse physio-chemical analyses. The terpolymeric gel showed pH-dependent release of DMOG as a bioactive molecule for osteogenesis and angiogenesis, and TCN as an antibiotic at 37 °C. The in vitro cell study results ascertained that the synthesized gel supported excellent MC3T3 cell adhesion, proliferation, and viability. The H&E, and MT staining results implied that the terpolymeric gel itself delivers proper environment for the regeneration of extracellular matrix and collagen after 3 weeks. Finally, the biocompatible gel could be used as matrix for DMOG and TCN delivery, as well as in bone tissue engineering applications. Reference: 1. Das et al., Colloids and Surfaces B: Biointerfaces, 2018, 170, 64-75. |
