| 학회 | 한국화학공학회 |
| 학술대회 | 2003년 가을 (10/24 ~ 10/25, 한양대학교) |
| 권호 | 9권 2호, p.2018 |
| 발표분야 | 분리기술 |
| 제목 | ASES Crystallization of Biodegradable Polymer Using Supercritical CO2 as an Anti-solvent |
| 초록 | The application of supercritical fluids for processing of pharmaceuticals has considerable interest in recent years. Some of the most recent studies have involved the use of supercritical fluids technology for the processing of the biodegradable polymers such as L-polylactic acid(L-PLA), polyglycolic acid(PGA), polycaprolactone(PCL)-all of which have been used extensively in the medical industry as carriers of pharmaceuticals. Micro particles of polylactic acid(PLA) were generated by aerosol solvent extraction system(ASES) using supercritical CO2 as an anti-solvent. The experimentswere performed by changing variables such as pressure(75-150bar), temperature(25-40℃), initial concentration(0.3-3wt%), solution flow rate (0.3-2.3ml/min). And nozzle diameter was kept unchanged in the all of the experiments that were carried out. It was found that ASES gives fine particle size and size distribution by simple operation of the process parameters. The particle size and morphology were studied using Scanning Election Microscopy(SEM). |
| 저자 | 정헌섭1, 이정우1, 이창하2, 임종성1, 이윤우1 |
| 소속 | 1한국과학기술(연), 2연세대 |
| 키워드 | Biodegradable polymer;Polycaprolactone;Aerosol solvent extraction system;Atomization;Diffusivity;Recrystallization |
| 원문파일 | 초록 보기 |
