| 초록 |
A biodegradable polycaprolactone (PCL) is used as a coating material on drugs for microencapsulation in various solvents, and this microencapsulation is applicable to drug delivery system. In case drugs were encapsulated by a coating material, the manufacturing condition and method could be changed according to the solubility of coating materials in solvent, so the solubility data are requisite. In this work, we measured cloud points using an apparatus with variable volume cell to get data on the solubility of PCL in solvents such as HCFC-22, HFC-143a and DME. PCL was dissolved well in HCFC-22 and DME below 37MPa, and the cloud points of this were measured with the concentrations in solvents. On the other hand, PCL was not dissolved in HFC-143a. We also investigated the effect of CO2 on the cloud point of PCL as adding CO2 into HCFC-22, DME. The cloud point pressure of PCL increased proportionally to the amount of CO2 added at the same temperature. According to this result, CO2 could be used as an anti-solvent, and the cloud point of PCL could be controlled by changing the concentration of CO2. |
