| 초록 |
The concentration of glutathione (reduced form) is higher around tumor cells than normal cells. Based on this fact, poloxamer disulfide was prepared. In-vitro study showed that the polymer system not only improved the short gel duration problem of the poloxamer but also released the incorporated drug in a glutathione dependent manner. The 40 % (by volume) of the poloxamer disulfide gel was eroded in phosphate buffer four weeks, whereas P85 and F127 gels were completely eroded in 6 hours and 22 hours, respectively. 57 % of paclitaxel was release from the in situ formed poloxamer disulfide hydrogel over 12 hours in the glutathione concentration of 80 mM whereas 5 % of the drug was released in the absence of the glutathione. This system can be a model in designing a disease responsive drug delivery system. |
